Scientific Researches On Moringa

The National Institutes of Health

The National Institutes of Health (NIH), part of the U.S. Department of Health and Human Services, and the primary Federal agency for conducting and supporting medical research has started to pay attention to Moringa oleifera. A recent article in the March 2008 issue of NIH Record held a “mystery plant challenge”. They praise the plant and mention "...perhaps like no other single species, this plant has the potential to help reverse multiple major environmental problems and provide for many unmet human needs.www.treeoflife.myzija.com/moringa.html

John Hopkins School of Medicine

Recent report from John Hopkins School of Medicine on Moringa : http://www.tfljournal.org/article.php/20051201124931586

Moringa Promotes:
Normal Liver and Kidney Function
Healthy Digestion
Healthy Circulatory System
Normal Serum Cholesterol
Healthy Cell Structure
Normal Blood Glucose Levels
Healthy Skin
Reduces the Appearance of Fine Lines and Wrinkles
Inflammations and arthritis pains reduced
Tumors restricted and ulcers healed
Headaches and Migraines handled
Nourishes Body's Immune System
Nourishes the Eyes and Brain
Increases Energy
sleep Aid

Possible Role of Moringa oleifera Lam. Root in Epithelial Ovarian Cancer
Chinmoy K. Bose, MD, PhD, ex-postdoctoral fellow; Specialist Medical Officer; Honorary Research Fellow
Chinmoy K. Bose, St. Bartholomew's Hospital, London, UK; The Kolkata Municipal Corporation, Kolkata; Medical College, College Street, Kolkata, India Author's Email: ckbose@hotmail.com .

Disclosure: Chinmoy K. Bose, MD, PhD, has disclosed no relevant financial relationships

Age-specific incidence of epithelial ovarian cancer indicates a hormonal etiology and relates it to menopause, a time during the aging process when ovaries fail but the pituitary becomes overactive to produce a greater amount of gonadotropins. There is a 10-fold to 20-fold increase in the follicle-stimulating hormone (FSH) level and a 3-fold to 5-fold increase in the luteinizing hormone (LH) level in blood in menopause. Naturally, gonadotropins, especially follicle stimulating hormone (FSH) and its receptor (FSHR), are implicated as endogenous carcinogens for ovarian cancer.[1,2] Zheng and colleagues[3] demonstrated the presence of FSHR in innocuous postmenopausal ovarian surface epithelium (OSE) from where this cancer originates. This was the first study to provide evidence that OSE is hormonally active. These findings points to the need for new therapies to treat epithelial ovarian cancer encompassing natural and synthetic substances that have both anticancer and hormonal properties.


An antitumor promoter from Moringa oleifera Lam.
Guevara A.P. Vargas C. Sakurai H. Fujiwara Y. Hashimoto K. Maoka T. Kozuka M. Ito Y. Tokuda H. Nishino H.
Institute of Chemistry, College of Science, University of the Philippines, Diliman, Quezon City, Philippines
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 6 April 1999, vol. 440, no. 2, pp. 181-188(8) E lsevier Science (Journal article, isbn: 1383-5718)
Abstract:
In the course of studies on the isolation of bioactive compounds from Philippine plants, the seeds of Moringa oleifera Lam. were examined and from the ethanol extract were isolated the new O-ethyl-4-( -l-rhamnosyloxy)benzyl carbamate (1) together with seven known compounds, 4( -l-rhamnosyloxy)-benzyl isothiocyanate (2), niazimicin (3), niazirin (4), -sitosterol (5), glycerol-1-(9-octadecanoate) (6), 3-O-(6'-O-oleoyl- -d-glucopyranosyl)- -sitosterol (7), and -sitosterol-3-O- -d-glucopyranoside (8). Four of the isolates (2, 3, 7, and 8), which were obtained in relatively good yields, were tested for their potential antitumor promoting activity using an in vitro assay which tested their inhibitory effects on Epstein-Barr virus-early antigen (EBV-EA) activation in Raji cells induced by the tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA). All the tested compounds showed inhibitory activity against EBV-EA activation, with compounds 2, 3 and 8 having shown very significant activities. Based on the in vitro results, niazimicin (3) was further subjected to in vivo test and found to have potent antitumor promoting activity in the two-stage carcinogenesis in mouse skin using 7,12-dimethylbenz(a)anthracene (DMBA) as initiator and TPA as tumor promoter. From these results, niazimicin (3) is proposed to be a potent chemo-preventive agent in chemical carcinogenesis.

Hypotensive constituents from the pods of Moringa oleifera
Faizi, Shaneen Siddiqui, B.S. Saleem, R. Aftab, K. Shaneen, F. Gilani, A.
H. E. J. Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan.
Planta medica. [ Planta med.. ] 1998 , vol. 64 , no 3 , pp. 225 - 228 (Journal article, isbn: 0032-0943)
Abstract:
Hypotensive activity of the ethanolic and aqueous extracts of Moringa oleifera whole pods and their parts, namely, coat, pulp, and seed was investigated. The activity of the ethanolic extract of both the pods and the seeds was equivalent at the dose of 30 mg kg. The ethyl acetate phase of the ethanolic extract of pods was found to be the most potent fraction at the same dose. Its bioassay-directed fractionation led to the isolation of thiocarbamate and isothiocyanate glycosides which were also the hypotensive principles of the pods as observed in case of Moringa leaves. Two new compounds, O-[2'-hydroxy-3'-(2 -heptenyloxy)]-propyl undecanoate (1) and O-ethyl-4-[( -L-rhamnosyloxy)-benzyl] carbamate (2) along with the known substances methyl p-hydroxybenzoate (3) and -sitosterol have also been isolated in the present studies. The latter two compounds and p-hydroxybenzaldehyde showed promising hypotensive activity. Structures of all these compounds have been deduced by spectroscopy and chemical reactions.
Keywords: plant composition; pods; cardiovascular system; sterols; phenolic compounds; pharmacology

Studies on some psychopharmalogical actions of Moringa oleifera Lam. Moringaceae) Leaf extract
Pal, M. Mukherjee, P. K. Saha, B. P. Pal, M. Saha, B. P.
DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY, FACULTY OF ENGINEERING AND TECHNOLOGY, JADAVPUR UNIVERSITY
PTR. Phytotherapy research.1996 , vol. 10 , no 5 , pp. 402 - 405 (Journal article)
Abstract:
The methanol extract of the leaves of Moringa oleifera Lam. was investigated for some psychopharmacological actions in animals. The extract was found to produce a significant alteration in general behavioural pattern by head dip test, Y-maze test, evasion test, and reduction in muscle relaxant activity by rotarod test, chimney test and traction test. Beside these, the extract also potentiated pentobarbitone induced sleeping time and lowered body temperature in experimental animals.



Share the story and bring this amazing product to the rest of the world.
www.TreeOfLife.myzija.com